It is difficult to provide detailed guidance on how much/little adaptation is appropriate or how much on an original TMF must be maintained (e.g. How many constructs can I change? What are the core elements of a TMF?). Like the other sections of this tool, there is not a single “cookbook” approach to TMF adaptation, every situation is different and every study is different. It helps to have someone on your team with experience in implementing and using TMFs and to work with your stakeholders who can inform what adaptations are needed for the D&I TMF to be relevant to your context. Along the way, documenting adaptations and the reasons for those adaptations is important.